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Symbol
Name
ID 		Lta
lymphotoxin A
MGI:104797
Phenotype annotations related to immune system
Darker colors indicate more annotations
Human Phenotypes
Sinusitis
Chronic sinusitis
Keratoconjunctivitis sicca
Abnormality of the spleen
Hepatosplenomegaly
Pancreatitis
Uveitis
Recurrent pneumonia
Autoimmunity
Asthma
Nontuberculous mycobacterial pulmonary infection
Recurrent Burkholderia cepacia infections
Recurrent Haemophilus influenzae infections
Recurrent Staphylococcus aureus infections
Recurrent Aspergillus infections
Recurrent respiratory infections
Recurrent bronchopulmonary infections
Recurrent lower respiratory tract infections
Disease(s) Associated with LTA
asthma
cystic fibrosis
leprosy
neovascular inflammatory vitreoretinopathy
Sjogren's syndrome
type 1 diabetes mellitus

Mouse Phenotypes
impaired macrophage phagocytosis
abnormal thymus epithelium morphology
abnormal thymus medulla morphology
small thymus medulla
insulitis
periinsulitis
enlarged spleen
increased spleen weight
abnormal lymphopoiesis
abnormal class switch recombination
decreased transitional stage B cell number
increased eosinophil cell number
increased neutrophil cell number
abnormal leukocyte cell number
absent marginal zone B cells
increased B-1b cell number
increased B cell number
decreased NK cell number
decreased T cell number
increased lymphocyte cell number
decreased monocyte cell number
increased leukocyte cell number
abnormal lymphocyte morphology
abnormal gamma-delta T cell morphology
abnormal spleen morphology
abnormal spleen white pulp morphology
decreased spleen B cell follicle number
absent spleen germinal center
abnormal spleen marginal zone morphology
absent spleen marginal zone
abnormal spleen periarteriolar lymphoid sheath morphology
decreased spleen white pulp amount
decreased IgA level
decreased IgG1 level
decreased IgG2a level
decreased IgG3 level
decreased IgG level
increased IgM level
decreased immunoglobulin level
decreased circulating interferon-gamma level
abnormal circulating tumor necrosis factor level
abnormal immune system morphology
abnormal lymph organ development
abnormal immune system organ morphology
absent Peyer's patches
abnormal lymph node morphology
absent mesenteric lymph nodes
abnormal lymph node primary follicle morphology
absent axillary lymph nodes
absent brachial lymph nodes
absent cervical lymph nodes
absent inguinal lymph nodes
absent popliteal lymph nodes
absent peripheral lymph nodes
absent lymph nodes
abnormal mucosa-associated lymphoid tissue morphology
abnormal humoral immune response
abnormal immune serum protein physiology
abnormal cytokine secretion
decreased interferon-gamma secretion
decreased tumor necrosis factor secretion
decreased susceptibility to experimental autoimmune encephalomyelitis
decreased susceptibility to induced arthritis
decreased susceptibility to endotoxin shock
liver inflammation
kidney inflammation
lung inflammation
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
decreased susceptibility to parasitic infection
increased susceptibility to parasitic infection
increased susceptibility to Poxviridae infection
increased susceptibility to Riboviria infection
Availability Mouse Genotype
Lta/Tnftm1Eug/Lta/Tnftm1Eug
Lta/Tnftm1Fda/Lta/Tnftm1Fda
Lta/Tnftm1Jods/Lta/Tnftm1Jods
Ltahlb382/Ltahlb382
Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Ltatm1.1Sned/Ltatm1.1Sned
Ltatm1Dch/Ltatm1Dch
Ltatm1Jods/Ltatm1Jods
Ltatm1Tab/Ltatm1Tab
Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Lta/Tnftm1Fda/Lta+
Tg(Ins2-Lta)#Flv/0
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory